Nexplanon can cause mild or serious side effects. Some examples of blood clots are deep vein thrombosis (legs), pulmonary embolism (lungs), retinal thrombosis (eyes), stroke (brain), and heart attack (heart). Last medically reviewed on June 19, 2022. These medicines will be used when the implant is placed into or removed from your arm. This fact poses the question of a primitive function for prolactin, which would explain its retention during premammalian evolution. But like other kinds of birth control, Nexplanon is not 100% effective. Spotting and other changes in bleeding are common with Nexplanon, but you should still tell your doctor if you experience these side effects. Pain. Nexplanon may raise your triglyceride or cholesterol levels. However, women who are nursing can use Nexplanon without presenting a health risk to the infant. In some cases, they may recommend a different birth control option for you. The drug comes as an implant thats inserted under the skin of your arm by a healthcare professional. These changes may continue as long as you have Nexplanon. Your healthcare provider may be able to help. Less commonly, large prolactinomas can cause compression of surrounding structures, e.g. Effect of chronic metoclopramide therapy on serum pituitary hormone concentrations. In men, high prolactin levels can cause: Milky . 1 Dr Molitch is currently receiving research support from Pfizer, Inc, Novartis Pharmaceuticals Corp, Sanofi-Aventis Pharmaceuticals, and Amgen Inc and is serving as a consultant to Abbott Laboratories., Address reprint requests and correspondence to Mark E. Molitch, MD, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, 303 E Chicago Ave (Tarry 15-731), Chicago, IL 60611, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill. Nexplanon may cause breast pain in some people. You should not use NEXPLANON if you are pregnant or think you may be pregnant; have or have had blood clots; have liver disease or a liver tumor; have unexplained vaginal bleeding; have breast cancer or any other cancer that is sensitive to progestin (a female hormone), now or in the past; or are allergic to anything in NEXPLANON. Possible side effects from having Nexplanon inserted or removed include: In studies of Nexplanon, side effects after the implant was inserted or removed werent common. Yes, Nexplanon may cause long-term changes in your period bleeding. signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools) symptoms of a urinary tract infection (e.g. Clozapine and risperidone in chronic schizophrenia: effects on symptoms, parkinsonian side effects, and neuroendocrine response. Overall, there is a highly variable PRL-releasing response to these drugs among individuals in both the level of PRL and the duration of PRL elevation. Your side effect notes can include things such as: Keeping notes and sharing them with your doctor will help them learn more about how Nexplanon affects you. Although thyrotropin-releasing hormone (TRH) causes a rapid release of PRL, numerous different experimental approaches have failed to clarify the physiological role of TRH as a PRL-releasing factor. But if you have any symptoms that are ongoing or bother you, talk with your doctor or pharmacist. Symptoms can be mild to serious and can include: If you have mild symptoms of an allergic reaction, such as a mild rash, call your doctor right away. Please read the accompanying .css-ozh8vf{transition-property:var(--chakra-transition-property-common);transition-duration:var(--chakra-transition-duration-fast);transition-timing-function:var(--chakra-transition-easing-ease-out);cursor:pointer;-webkit-text-decoration:none;text-decoration:none;outline:2px solid transparent;outline-offset:2px;color:var(--chakra-colors-text-link);font-family:var(--chakra-fonts-default);font-size:14px;font-weight:var(--chakra-fontWeights-bold);}.css-ozh8vf:hover,.css-ozh8vf[data-hover]{-webkit-text-decoration:underline;text-decoration:underline;}.css-ozh8vf:focus,.css-ozh8vf[data-focus]{box-shadow:var(--chakra-shadows-outline);}@media screen and (min-width: 40em){.css-ozh8vf{font-size:21px;}}Patient Information for NEXPLANON and discuss it with your healthcare provider. The average weight gain was nearly three pounds one year after implant and close to four pounds two years after implant. Nexplanon should not be used during pregnancy. These drugs cause hyperprolactinemia in more than 50% of patients and commonly cause symptoms of amenorrhea and galactorrhea in women and impotence in men. Examples include weight gain, nausea, and changes in period bleeding, such as spotting. Hormonal birth control such as Nexplanon may cause mood changes, including depression. The effects of paroxetine and tianeptine on peripheral biochemical markers in major depression. This observation is validated through an abnormal response to Thyrotropin . Nexplanon, the hormonal birth control implant, is more than 99 percent effective at preventing pregnancy; in fact, just five out of every 10,000 women using Nexplanon will get pregnant in one year. If you already have a mood disorder or depression, Nexplanon may make your condition worse. Talk with your doctor to determine which kind of contraceptive is best for you. Located at the base of the brain, the pituitary is a pea-sized gland that controls the production of many hormones. Effect of bromocriptine mesylate on induced hyperprolactinemia in stabilized psychiatric outpatients undergoing neuroleptic treatment. Often, the cause is a prolactin-making tumor on the pituitary gland, called a . Nexplanon is used to help prevent . Gallbladder disease. Nexplanon can cause side effects that range from mild to serious. Some clinical conditions resulting in high prolactin levels in non-pregnant females are; Idiopathic hyper-prolactinemia - Meaning no known cause (about 40% cases) Tumors of the . You can opt to never have a period or to have a, There are many birth control options and picking the one thats best for you can be a challenge. Back pain . You have an increased chance of getting blood clots during surgery or bed rest. It is possible to die from a problem caused by a blood clot, such as a heart attack or a stroke. 2005-2023 Healthline Media a Red Ventures Company. This was also the most common reason that people had their Nexplanon implant removed early. The hormones in the birth control implant prevent . In both sexes, the presence of a pituitary tumor may cause visual-field . If you have questions about possible side effects, talk with your doctor. Your thyroid can also cause elevated prolactin levels. Suppressed prolactin response to dynorphin A. The etonogestrel implant (trade name Nexplanon) is a single radioopaque plastic rod with 68 mg of etonogestrel which is placed subdermally in the upper arm, 8 cm proximal to the medial epicondyle; it is FDA approved for use for up to 3 years. A prolactinoma is the most common cause of hyperprolactinemia. Your doctor can check that the side effects youre experiencing are from Nexplanon and not another cause. Based on data from clinical trials of the non-radiopaque etonogestrel implant (IMPLANON): Women who use NEXPLANON are likely to have changes in their vaginal bleeding patterns. Although they werent common, these side effects were reported in people who had Nexplanon inserted or removed in studies. You can learn more about how we ensure our content is accurate and current by reading our. When the implant moves deeper into your arm, it can cause serious symptoms, such as: In very rare cases, its possible for the implant to enter the bloodstream and travel to other areas of the body, such as the chest or lungs. They may be able to recommend ways to manage this side effect, or they may suggest a different birth control option for you. It releases the hormone progestin to stop you from getting pregnant. Many acid-reducing alternatives can help ease GERD pain before taking Nexium, Prilosec or another PPI.Antacids help relieve GERD symptoms by neutralizing stomach acid. Dopamine is the predominant physiological inhibitory factor; blockade of endogenous dopamine receptors by various drugs, including antipsychotic agents, causes PRL secretion to increase. Levels of PRL increase usually within minutes after intramuscular injection. Undereating can also increase stress hormone levels which can lead to an increase in prolactin. If you cannot feel the NEXPLANON implant, contact your healthcare provider immediately and use a non-hormonal birth control method (such as condoms) until your healthcare provider confirms that the implant is in place. What to Know About Birth Control Options That Stop Your Period, 6 Most Important Things to Consider When Choosing Your Birth Control, 8 of the Best Birth Control Options to Ease Heavy Periods, Birth Control for Endometriosis: How It Works, Types, and Alternatives, How Government and Religious Organizations Can Affect Your Birth Control Options, Debra Sullivan, Ph.D., MSN, R.N., CNE, COI. ORGANON and the ORGANON Logo are trademarks of the Organon group of companies. Although these side effects werent reported in studies, theyve been reported by people who got Nexplanon after it was approved for use. Consider taking notes on any side effects youre having with Nexplanon. The prolactin response to neuroleptic drugs: a test of dopaminergic blockade: neuroendocrine studies in normal men. If this worries you, talk to your doctor or pharmacist about other options. However, the reference for this statement was a personal communication, and other evidence does not support this statement. If the implant cannot be found in the arm, your healthcare provider may use x-rays or other imaging methods on the chest. Other factors may also affect whether Nexplanon is a good treatment option for you. Again, such a substitution must be done extremely carefully with supervision of the patient's psychiatrist when the patient is taking a psychoactive medication. Implants have been found in the pulmonary artery (a blood vessel in the lung). Vasoactive intestinal peptide has stimulatory effects that are selective for PRL; also, a part of the vasoactive intestinal peptide precursor, a similarly sized peptide known as peptide histidine methionine, exerts PRL-releasing properties in humans. Hyperprolactinemia (High Prolactin Levels) | Causes, Signs & Symptoms, Diagnosis, TreatmentHyperprolactinemia is a medical condition that involves high level. In fact, weight gain was a common side effect reported in studies of Nexplanon. Published by Elsevier Inc. All rights reserved. flu-like symptoms, sore throat. Neuroendocrine response is the most common cause of hyperprolactinemia for this statement cause is a pea-sized gland that the... To manage this side effect, or they may be able to recommend ways to this. May continue as long as you have an increased chance of getting blood during... Can not be found in the arm, your healthcare provider may use x-rays or other methods... 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can nexplanon cause high prolactin tricor