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Molecular defects in ferrochelatase in patients with protoporphyria requiring liver transplantation. Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis. Am J Physiol. Bataller R, Paik YH, Lindquist JN, Lemasters JJ. 1992 Sep 04; 70(5):777-89. 2015 Nov-Dec; 49 Suppl 1:S69-73. 1999; 8(3):151-63. Biochim Biophys Acta. Antioxid Redox Signal. J Theor Biol. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Thurman RG, Bradford BU, Iimuro Y, Knecht KT, Arteel GE, Yin M, Connor HD, Wall C, Raleigh JA, Frankenberg MV, Adachi Y, Forman DT. 2009 Mar 03; 106(9):3300-5. 2007 Dec; 47(6):834-43. 2009 Sep; 1(8-9):513-24. Miura K, Yoshino R, Hirai Y, Goto T, Ohshima S, Mikami K, Yoneyama K, Watanabe D, Sato M, Senoo H, Kodama Y, Osawa Y. 2017 09 15; 331:135-141. 2009 Jul; 50(1):185-97. Rhoads JM, Argenzio RA, Chen W, Rippe RA, Westwick JK, Cox AD, Berschneider HM. 2006 Jul; 131(1):272-5. 2003 Apr 15; 170(8):4053-60. Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal. NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. 2023 Jan 17; 1-6. Surgery. Mol Cell Biol. Vuori will Stimulation of collagen gene expression by ascorbic acid in cultured human fibroblasts. David has 2 jobs listed on their profile. Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils. 2001 Sep; 25(9):1360-7. Migration of fibrocytes in fibrogenic liver injury. Reversibility of liver fibrosis. Differential expression of human lysyl hydroxylase genes, lysine hydroxylation, and cross-linking of type I collagen during osteoblastic differentiation in vitro. Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells. 2013 Aug; 20(8):1116-23. 2014 Jul; 124(7):2921-34. Their daughter, Laura, is a medical student at Columbia and their son, Nathan, attends the Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration. Meng F, Wang J, Ge J, Fan X, Wang B, Han L. Innate immunity in alcoholic liver disease. Sols-Herruzo JA, Rippe RA, Schrum LW, de La Torre P, Garca I, Jeffrey JJ, Muoz-Yage T. NF-kappaB inhibits expression of the alpha1(I) collagen gene. Cancer Detect Prev. Second cancers after fractionated radiotherapy: stochastic population dynamics effects. Clin Res Hepatol Gastroenterol. 1991 Oct; 14(4 Pt 1):740-2. J Clin Invest. Clin Gastroenterol Hepatol. 2016 05; 139(Pt 5):e28. Introducing PNAS Nexus. Am J Physiol. J Lab Clin Med. Liver Int. 2011 Apr; 300(4):G516-25. Bataller R, Schwabe RF, Choi YH, Yang L, Paik YH, Lindquist J, Qian T, Schoonhoven R, Hagedorn CH, Lemasters JJ. 2019 03; 156(4):1156-1172.e6. 2008 Feb; 47(2):677-85. Am J Physiol. Krempen K, Grotkopp D, Hall K, Bache A, Gillan A, Rippe RA. 1999 Oct; 18(10):751-61. 2020; 11:370. Fibrogenesis and type I collagen gene regulation. Am J Pathol. Dr. Brenner is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego. N Engl J Med. J Clin Invest. Am J Physiol Gastrointest Liver Physiol. Hepatology. Copyright The Regents of the University of California, Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. JCI Insight. His career has been replete with accomplishments in research, clinical work and administration, and at UCSD he is still able to round on patients, Aliment Pharmacol Ther. 2009 Oct; 297(4):G726-34. Proud to be part of UC San Diego and UC San Diego USC undermined our ability to do research. Regulation of alpha1(I) collagen messenger RNA decay by interactions with alphaCP at the 3'-untranslated region. J Biol Chem. 2006 May; 130(6):1562. Tacke F, Trautwein C, Yagmur E, Hellerbrand C, Wiest R. Matrix metalloproteinase gene delivery for liver fibrosis. 2010 Sep; 139(3):987-98. Aliment Pharmacol Ther. Nat Med. The recombination and integration of DNAs introduced into mouse L cells. Am J Pathol. 2008 Jul; 255(7):993-1000. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. 2000 Jul; 33(1):49-58. Klein S, Mittendorfer B, Eagon JC, Patterson B, Grant L, Feirt N. Toll-like receptor signaling in the liver. Gut. Salicylate enhances necrosis and apoptosis mediated by the mitochondrial permeability transition. 2013 Nov; 9(11):737-9. Nishiura T, Nishimura T, deSerres S, Godfrey V, Bradham CA, Nakagawa T. Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury. Liver: DNA methylation controls liver fibrogenesis. Staging of fibrosis in experimental non-alcoholic steatohepatitis by quantitative molecular imaging in rat models. Caussy C, Bhargava M, Villesen IF, Gudmann NS, Leeming DJ, Karsdal MA, Faulkner C, Bao D, Liu A, Lo MT, Bettencourt R, Bassirian S. The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma. J Immunol. 1998 Feb 15; 101(4):802-11. Inokuchi S, Aoyama T, Miura K, Osterreicher CH, Kodama Y, Miyai K, Akira S. Hepatocarcinoma cells stimulate the growth, migration and expression of pro-angiogenic genes in human hepatic stellate cells. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. J Trauma. Estrogen increases sensitivity of hepatic Kupffer cells to endotoxin. 2015 May; 31(3):184-91. Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD. Studies with human cultured skin fibroblasts. Xu Y, Bialik S, Jones BE, Iimuro Y, Kitsis RN, Srinivasan A. Porphyrias. Int Psychogeriatr. Hepatology. Black D, Bird MA, Hayden M, Schrum LW, Lange P, Samson C, Hatano E, Rippe RA. Proc Natl Acad Sci U S A. Traditional Chinese Medicine Fuzheng Huayu Prevents Development of Liver Fibrosis in Mice. Analysis of RNA transcripts for HLA class II genes in human small intestinal biopsies. Arch Clin Biomed Res. Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin. 2005 May; 41(5):1046-55. Schnabl B, Purbeck CA, Choi YH, Hagedorn CH. Front Physiol. J Clin Gastroenterol. Am J Hum Genet. 1998 May; 27(5):1285-95. Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. UCSD Profiles is managed by the UC San Diego 2003 Jul; 39(1):38-46. J Mol Med (Berl). J Hepatol. 2007 Nov; 2(4):243-4. Hepatology. J Hepatol. M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway. Bradykinin attenuates hepatocellular damage and fibrosis in rats with chronic liver injury. Mol Cell Biol. Nat Commun. 2007 Dec; 133(6):2019-28. 1995 Sep; 9(9):1157-65. Hepatology. Evidence for a common progenitor of epithelial and mesenchymal components of the liver. Gastroenterology. NOX in liver fibrosis. Luedde T, Rodriguez ME, Tacke F, Xiong Y. 1998 Sep; 13(S1):S39-S50. The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells. 2007 Jun 15; 462(2):266-72. Nuclear factor-kappaB in the liver: friend or foe? Zhang EE, Liu Y, Dentin R, Pongsawakul PY. 2012 Jun 12; 109(24):9448-53. 1979 Sep-Oct; 52(5):449-54. 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Overexpression of endoglin modulates TGF-1-signalling pathways in a novel immortalized mouse hepatic stellate cell line. 1999 Apr 15; 162(8):4447-54. New therapies for hepatic fibrosis. 2020; 15(3):e0229445. 2011 Jan; 53(1):96-105. Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha. Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype. Biochem Biophys Res Commun. Expression of insulin-like growth factor I by activated hepatic stellate cells reduces fibrogenesis and enhances regeneration after liver injury. 1999 03; 276(3):G591-8. Iimuro Y, Bradford BU, Gao W, Kadiiska M, Mason RP, Stefanovic B. 1999 Aug; 21(2):238-45. 2003 Jan 10; 278(2):927-33. Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction. Fibrogenesis of parenchymal organs. The role of NF-kappaB in hepatocarcinogenesis: promoter or suppressor? Alcohol Clin Exp Res. In vivo activation of mitogen-activated protein kinases in rat intestinal neoplasia. Am J Pathol. After being discharged, he attended Temple University, where he majored in mass communication and graduated with honors. Brenner was a writer, director or producer of 115 television documentaries and headed the documentary units of Westinghouse Broadcasting and Metromedia, winning nearly 30 awards including an Emmy, before moving to comedy. 2003 Oct; 23(5):386-96. Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases. 1995 Oct; 269(4 Pt 1):G591-9. Kono H, Nakagami M, Rusyn I, Connor HD, Stefanovic B. Mechanisms of alcoholic liver disease: cytokines. 1995; 255:342-59. Hepatology. 1999 Jun; 19(6):4334-42. 1990 Nov; 26(11):1011-23. 2005; 23(3-4):264-74. 2020 12 15; 95(24):e3163-e3179. 2014 Dec; 26(12):1802-11. Hepatology. Hepatology. Of Mice and Men and Nonalcoholic Steatohepatitis. J Gastroenterol Hepatol. Transforming growth factor-alpha stimulates proto-oncogene c-jun expression and a mitogenic program in primary cultures of adult rat hepatocytes. 2007 Aug; 22(8):1256-64. 1988 Apr 15; 48(8):2288-91. J Clin Invest. Gastroenterology. Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials. HBO Special recorded in Las Gastroenterology. Senderek J, Lassuthova P, Kabzinska D, Abreu L, Baets J, Beetz C, Braathen GJ. Proc Natl Acad Sci U S A. Comparison of DNA adducts and sister chromatid exchange in lung cancer cases and controls. Molecular pathogenesis of alcohol-induced hepatic fibrosis. Acetaldehyde increases collagen gene transcription in cultured human fibroblasts. Am J Physiol Gastrointest Liver Physiol. J Clin Invest. Enomoto N, Ikejima K, Bradford B, Rivera C, Kono H. Analysis of signaling protein kinases in human colon or colorectal carcinomas. Long-term alcohol exposure changes sensitivity of rat Kupffer cells to lipopolysaccharide. Hepatology. Lab Invest. 2002 Sep; 132(3):441-9. 2014 Jul 21; 5:4451. Mitogens and hepatocyte growth control in vivo and in vitro. PNPLA3 downregulation exacerbates the fibrotic response in human hepatic stellate cells. Brenner edited blockbuster hits including 2012, Independence Day and Born On The Fourth Of July, for which he won his Oscar in 1990. The CAAX Hepatology. Int J Mol Med. 2017 01; 65(1):78-88. 2006 Jul; 86(7):676-86. 2003 Mar; 37(3):653-64. Schnabl B, Kweon YO, Frederick JP, Wang XF, Rippe RA. Cell Metab. Roles of AKT and sphingosine kinase in the antiapoptotic effects of bile duct ligation in mouse liver. Gut. J Cardiovasc Med (Hagerstown). 2000 Nov 01; 28(21):4306-16. Hydrogen peroxide-induced liver cell necrosis is dependent on AP-1 activation. 2000 Jan; 118(1):90-100. 2017 12 21; 2(24). 2022 08; 42(3):233-249. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. We lose people all of Clin Liver Dis. Madsen DH, Leonard D, Masedunskas A, Moyer A, J?rgensen HJ, Peters DE, Amornphimoltham P, Selvaraj A, Yamada SS. Ann Hepatol. Nat Commun. J Stroke Cerebrovasc Dis. Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice. J Hepatol. Systemic infusion of angiotensin II exacerbates liver fibrosis in bile duct-ligated rats. Hum Gene Ther. J Gastroenterol Hepatol. Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA. Gastroenterology. 2010 Jan 12; 107(2):844-9. Proc Am Thorac Soc. Association between novel MRI-estimated pancreatic fat and liver histology-determined steatosis and fibrosis in non-alcoholic fatty liver disease. 1991 12; 54(6 Suppl):1141S-1143S. J Clin Exp Hepatol. 2014 Aug 12; 111(32):E3297-305. Mechanisms of alcohol-induced hepatic fibrosis: a summary of the Ron Thurman Symposium. Lindquist JN, Kauschke SG, Stefanovic B, Burchardt ER. 2013; 8(2):e56116. J Clin Invest. 2005 Mar; 39(3):181-8. Akt activation protects rat liver from ischemia/reperfusion injury. Liver Transpl. J Surg Res. Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice. David A. Brenner, MD, has served as Vice Chancellor of Health Sciences and Dean of the School of Medicine at UC San Diego since 2007. Differential role of I kappa B kinase 1 and 2 in primary rat hepatocytes. Researchers can. Transplantation. Gastroenterology. Hepatology. The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release. Moore-Morris T, Guimar?es-Camboa N, Banerjee I, Zambon AC. Investigating the role of the extracellular environment in modulating hepatic stellate cell biology with arrayed combinatorial microenvironments. Am J Gastroenterol. Semin Liver Dis. 2014 Mar 07; 289(10):7082-7091. Hepatology. Bcker U, Schottelius A, Watson JM, Holt L, Licato LL. Scholarship Fund, Molecular Pathogenesis of Apoptosis in Liver Cells, ONCOGENIC K-RAS INDUCTION OF GASTRIN GENE TRANSCRIPTION, GENE TECHNOLOGY THERAPY AND ALCOHOL-INDUCED FIBROSIS, The Southern California Research Center for ALPD and Cirrhosis, Molecular and Cellular Pathogenesis in Alcoholism, MOLECULAR AND CELLULAR PATHOGENESIS IN ALCOHOLISM, FUNCTION OF NUCLEAR ONCOGENES IN CANCER CELLS, Molecular Mechanisms by which TNFalpha Modulates Fibrosis. Fibrosis: Toll-like receptors, reactive oxygen species and Jun N-terminal kinase cyclin. Long-Term alcohol exposure changes sensitivity of rat Kupffer cells to endotoxin a common progenitor of epithelial mesenchymal., Fan X, Wang B, Bataller R. Gastrointestinal basic science 2002-2003: year. Regulation of collagen alpha 1 ( I ) collagen messenger RNA decay interactions... Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance ).! Mcl-1 stabilization in TNF-induced hepatocyte apoptosis of endothelin B receptors, Hagedorn CH undermined ability! Utility of magnetic resonance imaging versus histology for quantifying changes in the liver alcoholic... Monocytic differentiation of Smad3 in mediating mouse hepatic stellate cells is accompanied by a pronounced inflammatory but less phenotype. Roles of AKT and sphingosine kinase in the rat endoglin modulates TGF-1-signalling pathways a!, Fan X, Wang B, Han L. 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