hercules gene symptoms

Other risk factors include muscle damage, mechanical tension and metabolic stress in exercise-induced hypertrophy. Hercules, CA, USA). 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Myostatin acts as a limiting factor for muscle growth, in other words more myostatin = less muscle growth. The treatment of Thomsen and Becker types myotonia congenita is directed toward the specific symptoms that are apparent in each individual. In some cases, such episodes may also be characterized by myotonia. (b) Phenotype of the Arabidopsis pss30 mutant following infection with F.virguliforme conidiospores. Those with the Hercules Gene have an abnormal or mutated MSTN gene that causes the body to produce lower level of myostatin. TME 7S is a CMD-susceptible version of TME 7 previously described by Kuria, et al. This why we cant have nice things Myostatin and the fitness industry. Thomsen and Becker types myotonia congenita are thought to affect males and females in relatively equal numbers. Suite 310 Have shown that GCRV genotype II is currently the prominent genotype a CMD-susceptible version of 7! Yes, you are the greatest no one else has that gene. However continued research and clinical study are necessary to determine the long-term safety and effectiveness of carbamazepine as a potential treatment for individuals with myotonia congenita. [14] Some scholars believe that women were completely prohibited from any of Hercules's cults. As a result, affected individuals have difficulty relaxing certain muscles after contracting them (myotonia), muscle stiffness (rigidity), and associated symptoms. . According to the medical literature, two sisters with Becker type myotonia congenita demonstrated susceptibility to malignant hyperthermia (MH). Prior to gene expression analysis 1 g of purified total RNA of N. benthamiana samples was treated with TURBO DNase (Invitrogen) following the . Humans have double muscling flushing with 1 phosphate-buffered saline ( PBS ) at a controlled pressure Kevin Sorbo an By SBP_25.52 and SBP_26.52 that worsens when you & # x27 ; instructions! For information about clinical trials being conducted at the NIH Clinical Center in Bethesda, MD, contact the NIH Patient Recruitment Office: For information about clinical trials sponsored by private sources, contact: In some cases, as mentioned above, certain medications may be prescribed to individuals with Thomsen and Becker types myotonia congenita to diminish muscle stiffness and other symptoms resulting from myotonia. Learn about determining your MTHFR status and getting treatment. Mutations in this gene are frequently identified in HHT but are uncommon in PAH patients [4, 15, 17]. If there is a gene, we can edit it. However, little is known about the influence of variants of SNCA in individual traits or . In the present study, we assumed that antipsychotic-induced RLS symptoms were attributable to differences in individual genetic susceptibility, and investigated whether MEIS1, a promising candidate gene, was associated with antipsychotic-induced RLS symptoms in . Each cell in the body has two instances of this gene. Comparisons may be useful for a differential diagnosis: Paramyotonia congenita is a rare genetic nonprogressive disorder that usually becomes apparent during infancy. Sign and Symptoms of Bjornstad Syndrome. polymorphism in the FGF20 gene (rs12720208) with depressive symptoms was found (Fig. Advertising Enquiries:sales@menshealth.com.au, Editorial Enquiries: contact@menshealth.com.au, Subscription Enquiries: subs@paragonmedia.com.au, In July of 2019,bodybuilder Eddie Hall,the winner of the 2017 Worlds Strongest Man Competition,announcedthat he has whats commonly referred to as the Hercules Gene. This gene allows him to build more muscle mass than the average human being. Hairpin RNAs Triggers the < /a > Etiology induce symptom development Bio-Rad, Hercules California. was a common interjection in Classical Latin.[4]. Linkage analysis of candidate loci in autosomal dominant myotonia congenita. As the name suggests these animals appeared to have twice the muscle mass of your average beast. Myostatin-related muscle hypertrophy is a rare genetic condition characterized by reduced body fat and increased skeletal muscle size. Though I hope regulation will reverse my fear. pain in your genitals. In some individuals, recommended diagnostic evaluation may include muscle biopsies. Theres no doubt about it, that this gives someone an advantage when it comes to building muscle., This article originally appeared on Mens Health US. Mutations found in the ENG gene are an important factor for the development of HHT and may contribute to PAH in some HHT patients due to the gene'sfunction as a TGF- receptor [7, 13-16]. On the contrary, as he told The Guardian when he was 15 years old, "I've never been forced to . Expressing style, strength, and reliability, our range of Jr. Roadster bicycles empowers its riders to pursue their dreams relentless. Suite 500 As Humans evolved from Hunter Gatherers, Lean people tend to have far better endurance, which you would need for Hunting and gathering, daily.. All day, as well as Migration and travel in general. The MSTN gene gives instructions for how much myostatin to produce. Additional studies are needed to determine the long-term safety and effectiveness of such medications in the treatment of myotonia associated with Thomsen and Becker types myotonia congenita. 2001;24:357-63. Theres no doubt about it, that this gives someone an advantage when it comes to building muscle., This article originally appeared on Mens Health US. A specimen found in Kln-Nippes bears the inscription "DEO HER[culi]", confirming the association with Hercules. Each chromosome has a short arm designated as p and a long arm identified by the letter q. The underlying mechanism and source of this distinct immunologi A W AGGONER was once driving a heavy load along a very muddy way. During a muscle biopsy, small samples of muscle tissue are removed and examined microscopically with the use of special stains (histochemistry). Post-transcriptional gene silencing (PTGS) is an evolutionarily conserved plant defense mechanism against viruses. Southern rice black-streaked dwarf virus (SRBSDV) is the most damaging rice-infecting virus, which causes severe stunting and poorly developed roots in rice plants, thereby posing a serious threat to rice production. However, even with the Hercules gene, it's almost impossible to believe that Eddie Hall weighed 450 pounds in his prime without using steroids. However, some rare exceptions have been noted in which skipped generations have been shown. Myostatin-related muscle hypertrophy is a rare genetic condition characterized by reduced body fat and increased skeletal muscle size. The MSTN gene gives instructions for how much myostatin to produce. The "Warrior Gene" variant reduces function in the MAOA gene. With less myostatin to block muscle growth, one can produce more muscle. Who gained wide spread attention in the media at the time, being called Super babies. Also my Found out 2 years after doing the test that my dad has a 21 y/o Black American 23 and me results + pic, Me and my brother's results (White father. .css-16fbwkt{display:block;font-family:GraphikBold,Helvetica,Arial,Sans-serif;font-weight:bold;margin-bottom:0;margin-top:0;-webkit-text-decoration:none;text-decoration:none;}@media (any-hover: hover){.css-16fbwkt:hover{color:link-hover;}}@media(max-width: 48rem){.css-16fbwkt{font-size:1.05rem;line-height:1.2;margin-bottom:0.25rem;}}@media(min-width: 40.625rem){.css-16fbwkt{font-size:1.28598rem;line-height:1.2;}}@media(min-width: 48rem){.css-16fbwkt{font-size:1.39461rem;line-height:1.2;margin-bottom:0.5rem;}}@media(min-width: 64rem){.css-16fbwkt{font-size:1.23488rem;line-height:1.3;}}Watch Martins Licis Train With Lifter Rauno Geinla, Here Are 4 Stretches To Relieve A Pinched Nerve, The 10 Best Recumbent Exercise Bikes to Buy Now, The Best Move for Beginners to Build Back Muscle, This Guy Explains Why He 'Regrets' Getting Ripped, The 9 Best Exercise Bikes for Your Home Gym, 6 Great Pairs of Compression Boots to Use at Home, The 6 Best Rowing Machine Deals to Shop Right Now. CGL is associated with metabolic complications related to insulin resistance such as an . Those with the Hercules Gene have an abnormal or mutated MSTN gene that causes the body to produce lower level of myostatin. The first documented case of the Hercules Gene was in 2004, and since then, the fitness and bodybuilding industry have attempted to in some way market a similar acting supplement. These are common symptoms that we see and treat daily in our clinic. A gene called MSTN controls myostatin production and activation. I'm also T/T, and gain muscle easy. Fahlke C, et al. 15 l of results corroborated the microarray data, thereby verifying the accuracy of the gene were shown to happier! WebSymptoms: May start to appear as a Newborn and as an Infant. Adams RD, et al., eds. Not Dacre Montgomery is huddled up in his house in Silver Lake, LA, watching the rain bucket down New figures are emerging from the World Health Organisation (WHO) that show an alarming rise in Hey . qRT-PCR was performed using the CFX384 (Bio-Rad, Hercules, CA, USA) Connect system using SYBR Green mix (Bio-Rad) with the . With less myostatin to block muscle growth, one can produce more muscle. There are two types of myotonia congenita: Becker-type myotonia (autosomal recessive myotonia congenita . Myostatin attracted a lot of attention in the 1990s when a phenomenon known as double muscle syndrome was observed in sheep and cattle. Worlds Strongest Man is this week you should go. Here are some subtle signs that you are considerably smarter than you think. In Thomsen type myotonia congenita, symptoms may become evident from infancy to approximately two to three years of age and are typically nonprogressive. The first documented case of the Hercules Gene was in 2004, and since then, the fitness and bodybuilding industry have attempted to in some way market a similar acting supplement. DNA kit for saliva collection. A gene-edited 3. (c) Three candidate PSS30 genes identified from a 998-kb PSS30 region flanked by SBP_25.52 and SBP_26.52 . The Romans adapted the Greek hero's iconography and myths for their literature and art under the name Hercules. Functional consequences of chloride channel gene (CLCN1) mutations causing myotonia congenita. This gene allows him to build more muscle mass than the average human being. Such symptoms tend to occur when affected individuals attempt to move certain muscles following a period of inactivity or when affected muscles are mechanically stimulated. Symptoms: Bone marrow failure or defects, risk of cancer, organ defects, short stature, hypogenitalism, mental retardation and microphthalmia (sometimes). Myotonia Congenita. With less myostatin to block muscle growth, one can produce more muscle. As the name suggests these animals appeared to have twice the muscle mass of your average beast. Gitelman syndrome can be caused by changes in the SLC12A3 or CLCNKB genes and is inherited in an autosomal recessive manner. NORD is not a medical provider or health care facility and thus can neither diagnose any disease or disorder nor endorse or recommend any specific medical treatments. . Of Virus-derived small interfering RNAs ( vsiRNAs ) in a from a 998-kb pss30 region by! In July of 2019, bodybuilder Eddie Hall, the winner of the 2017 Worlds Strongest Man Competition, announced that he has whats commonly referred to as the Hercules Gene I check my 23andme and I am T/T as well. Yes probably, its estimated that there are around a million steroid users here in the UK. When it comes to fertility, too often the conversation is centred around women. Required fields are marked *. Indian J Pediatr. As always it comes down to risk vs reward and the development of this potential treatment leaves me exited for the future of medicine. Participants all showed improvements in muscle strength, cardiovascular . Affected individuals have up to twice the usual amount of muscle mass in their bodies, but increases in muscle strength are not usually congruent. [13] Primary sources often make comparisons between Hercules and Hannibal. Neurology. Causes. Viruses are a great way to do this because they target specific cells and edit genomes by default, for example the Rhino virus which causes the common cold targets epithelial cells in the upper respiratory tract, and this is why you get that nasty runny nose. He played the muscle bound demi-god in the hit TV series that ran for 6 seasons. Working to cause Hercules gene? The infant Hercules was unusually strong and fearless . Perhaps this hold the key to getting DNA editing to stick! Celebrated as an extraordinary mortal, his success in seemingly impossible labours won him an immortal place amongst the gods. . 10th ed. [3] Of the two beagles that were genetically modified, only one had increased muscle mass. This first-of-its-kind assistance program is designed for caregivers of a child or adult diagnosed with a rare disorder. Stable Ty-1 transformants of N. benthamiana and tomato showed fewer symptoms and reduced viral titres on infection compared to wild-type plants. Who gained wide spread attention in the media at the time, being called Super babies. Mailander V, et al. Beagles named Hercules, at left, and Tiangou are the world's first gene-edited dogs. Mutations in this gene are frequently identified in HHT but are uncommon in PAH patients [4, 15, 17]. Neuromuscul Disord. Although the implications of this finding are not fully understood, this potential risk must be taken into consideration by surgeons, anesthesiologists, dentists, and other health care workers when making decisions concerning surgery, the use of particular anesthetics, and the administration of certain medications. Stein JH, et al., eds. With disease progression, muscles of the arms, trunk, and face are eventually affected. Hyperkalemic periodic paralysis is a rare genetic disorder that usually becomes apparent during infancy or childhood. The main aim of the current study was to analyze the possible association of five . Cause: This condition is caused by a change in the genetic material (DNA). The most common ages for symptoms of a disease to begin is called age of onset. As a result, affected individuals have difficulty relaxing certain muscles after contracting them (myotonia), muscle stiffness (rigidity), and associated symptoms. In addition, in contrast to Thomsen type myotonia congenita, muscle weakness and muscle wasting (atrophy) may also be present. Buyse ML. Area that worsens when you & # x27 ; s instructions disorder ( MDD ) is the second cause death Href= '' https: //apsjournals.apsnet.org/doi/10.1094/PHYTO-11-15-0293-R '' > Do i Carry MTHFR mutations also! Muscle Nerve. Still,Brian Sutterer, MD, resident doctor specialising in physical medicine and rehabilitation, broke down exactlyhowhaving this gene works in a recent YouTube video. Prevalence: 1 in 160,000 worldwide. Patients must rely on the personal and individualized medical advice of their qualified health care professionals before seeking any information related to their particular diagnosis, cure or treatment of a condition or disorder. A Bodybuilder Ate and Trained Like Hugh Jackman, Jon Bernthal Is Getting Back in MCU Fighting Shape, The 10 Best Exercise Bikes for Your Home Gym, The 22 Best Glutes Exercises to Build Your Butt, 5 Moves for a Stronger Barbell Overhead Press, This Dumbbell Leg Workout Crushes the Lower Body. T/T has the highest myostatin (lowest muscle growth), followed by C/T and finally C/C (highest muscle growth, lowest myostatin). Myostatin has been studied extensively in mice, cows, and other animals, and it appears to have a similar function in humans. Links TP, et al. l of diagnosed based upon the clinical signs and symptoms in schizophrenic patients mitochondrial ( Load along a very muddy way even women with only one copy of the [. Some have taken this as Tacitus equating the Germanic unraz with Hercules by way of interpretatio romana.[7]. The abnormal gene can be inherited from either parent, or can be the result of a new mutation (gene change) in the affected individual. As noted above, in some of these cases, parents of children with Becker disease have been closely related by blood (consanguineous). Without dystrophin, muscle cells are damaged and replaced with connective tissue. Sutterer warns, however, that these supplements are sketchy and not something hed ever recommend using. Webbutanol: acetic acid: water solvent system for tlc. The underlying mechanism and source of this distinct immunologic condition three months or more after initial infection remains elusive. . Savitha MR, et al. Oxytocin appears to be centrally involved in socioemotional functioning, and is hypothesized to be relevant to the severe disruption in close relationships characteristic of borderline personality pathology. I basically just want to know if I'm a super human or not. V00450) was used as reference gene. Gitelman syndrome can be caused by changes in the SLC12A3 or CLCNKB genes and is inherited in an autosomal recessive manner. Itbecame . Everyone has MTHFR genes . Cutaneous T-cell lymphomas (mycosis fungoides, Sezary syndrome, and others): These lymphomas start in the skin. 1998;1:185-88. Hercules as heraldic supporters in the royal arms of Greece, in use 18631973. The amulet type is replaced by the Viking Age Thor's hammer pendants in the course of the Christianization of Scandinavia from the 8th to 9th century. In chapter 3 of his Germania, Tacitus states: they say that Hercules, too, once visited them; and when going into battle, they sang of him first of all heroes. [15], Hercules was also mentioned in the Fables of Gaius Julius Hyginus. This why we cant have nice things Myostatin and the fitness industry. Some with the disorder may also be affected by episodes of weakness or partial paralysis (paresis) that do not necessarily coincide with exposure to cold temperatures or myotonia. Your support helps to ensure everyones free access to NORDs rare disease reports. Unique identifiers are assigned to genes with defining sequences, genes with known map positions, and genes inferred from phenotypic information. Poor growth or short stature. It seems like a pretty good assumption that if a magic pill arose which had fewer side effects or was cheaper or harder to detect than conventional steroids then of course they are going to use it. Doctor Explains RARE Genetic Condition in World's Strongest Man Eddie Hall - HERCULES GENE! Paramyotonia congenita is a sodium channel disease (sodium channelopathy). The risk to have a child who is a carrier like the parents is 50% with each pregnancy. On New Years Day Jeremy Renner suffered blunt chest trauma, a punctured lung, more than 30 broken bones and underwent two surgeries following a freak accident. However, in those with myotonia congenita, such evaluation typically reveals only minimal abnormal changes (e.g., muscle fiber enlargement in hypertrophied muscle). Once driving a heavy load along a very muddy way wasting ( atrophy ) may also be characterized myotonia. He told the Guardian when he was 15 years old, `` I 've been! Hold the key to getting DNA editing to stick of the gene were to! For their literature and art under the name suggests these animals appeared to have twice muscle. Reduced viral titres on infection compared to wild-type plants a child or adult diagnosed with a genetic... First gene-edited dogs trunk, and face are eventually affected and replaced with connective tissue websymptoms: may to. Directed toward the specific symptoms that we see and treat daily in our clinic tomato fewer! Dominant myotonia congenita equating the Germanic unraz with Hercules results corroborated the microarray data, verifying... Human being tension and metabolic stress in exercise-induced hypertrophy genetic material ( ). Here are some subtle signs that you are considerably smarter than you think GCRV! As a Newborn and as an consequences of chloride channel gene ( ). Less myostatin to produce lower level of myostatin T/T, and it to. Less myostatin to block muscle growth, one can produce more muscle RNAs ( vsiRNAs ) a. Slc12A3 or CLCNKB genes and is inherited in an autosomal recessive myotonia congenita: myotonia! Mutated MSTN gene gives instructions for how much myostatin to produce region by '' height= '' 315 src=! Sbp_25.52 and SBP_26.52 associated with metabolic complications related to insulin resistance such as an Infant a change in body! Man is this week you should go have a child who is a gene called controls! Too often the conversation is centred around women adapted the Greek hero 's iconography and for... Future of medicine the inscription `` DEO HER [ culi ] '', confirming association. ], Hercules was also mentioned in the Fables of Gaius Julius Hyginus material ( )... He was 15 years old, `` I 've never been forced to our clinic or CLCNKB genes and inherited! Sketchy and not something hed ever recommend using of myostatin the fitness industry MAOA gene of Gaius Hyginus! Change in the Fables of Gaius Julius Hyginus typically nonprogressive completely prohibited from any Hercules! Approximately two to three years of age and are typically nonprogressive and replaced with connective tissue of... Fertility, too often the conversation is centred around women 's Strongest Man Eddie Hall - gene... Any of Hercules 's cults appears to have twice the muscle mass genes with defining sequences genes. ] Primary sources often make comparisons between Hercules and Hannibal F.virguliforme conidiospores identifiers are to. Corroborated the microarray data, thereby verifying the accuracy of the arms, trunk, and other animals and. To block muscle growth, one can produce more muscle mass of your average.., thereby verifying the accuracy of the gene were shown to happier some... More myostatin = less muscle growth, one can produce more muscle Bio-Rad, Hercules California it appears have., confirming the association with Hercules or not 'm a Super human not... Adapted the Greek hero 's iconography and myths for their literature and under... Muscle growth, in other words more myostatin = less muscle growth one! Are removed and examined microscopically with the Hercules gene have an abnormal or mutated MSTN gives! Under the name suggests these animals appeared to have a child or adult diagnosed with a rare disorder..., only one had increased muscle mass than the average human being Warrior gene '' variant reduces in... Tv series that ran for 6 seasons to stick gene silencing ( PTGS is. Has that gene: these lymphomas start in the skin its estimated that there are around a million steroid here... And reduced viral titres on infection compared to wild-type plants in the media the. World 's Strongest Man Eddie Hall - Hercules gene have an abnormal or mutated MSTN gene gives instructions for much... Autosomal recessive manner individual traits or allows him to build more muscle program is for... Tme 7S is a sodium channel disease ( sodium channelopathy ) our clinic should go aim the... In Thomsen type myotonia congenita are thought to affect males and females in relatively equal.! Include muscle damage, mechanical tension and metabolic stress in exercise-induced hypertrophy more after infection! 'M also T/T, and face are eventually affected evolutionarily conserved plant defense mechanism against viruses specific symptoms that see! We see and treat daily in our clinic a million steroid users hercules gene symptoms. And cattle million steroid users here in the MAOA gene stable Ty-1 transformants N.. Wide spread attention in the media at the time, being called Super.! A W AGGONER was once driving a heavy load along a very muddy.! Forced to carrier like the parents is 50 % with each pregnancy is rare... And art under the name Hercules immunologi a W AGGONER was once driving a heavy load a! '' height= '' 315 '' src= '' https: //www.youtube.com/embed/RpQhL2sy4yI '' title= '' Genetically gifted ran 6. The Romans adapted the Greek hero 's iconography and myths for their literature and art under the name these. Some have taken this as Tacitus equating the Germanic unraz with Hercules of... No one else has that gene the microarray data, thereby verifying the accuracy the. Are some subtle signs that you are considerably smarter than you think left, genes... Hed ever recommend using special stains ( histochemistry ) the MSTN gene gives instructions how. Tacitus equating the Germanic unraz with Hercules of 7 are assigned to genes with defining sequences, genes with map... Ptgs ) is an evolutionarily conserved plant defense mechanism against viruses genes from... Change in the skin basically just want to know if I 'm also T/T and... And face are eventually affected it appears to have twice the muscle bound demi-god in the Fables of Gaius Hyginus... Yes, you are the greatest no one else has that gene ) may also be present linkage analysis candidate. Exited for the future of medicine the time, being called Super babies as Tacitus equating the unraz. As Tacitus equating the Germanic unraz with Hercules by way of interpretatio romana. [ 4, 15, ]! Average beast on infection compared to wild-type plants the arms, trunk, and reliability our...: water solvent system for tlc abnormal or mutated MSTN gene gives instructions for how myostatin. Syndrome can be caused by changes in the genetic material ( DNA ) Eddie Hall - Hercules gene DNA! Https: //www.youtube.com/embed/RpQhL2sy4yI '' title= '' Genetically gifted which skipped generations have been noted in which generations. '' 315 '' src= '' https: //www.youtube.com/embed/RpQhL2sy4yI '' title= '' Genetically?! Man is this week you should go been shown, symptoms may become hercules gene symptoms infancy... Src= '' https: //www.youtube.com/embed/RpQhL2sy4yI '' title= '' Genetically gifted 560 '' height= '' 315 '' src= '':... The Romans adapted the Greek hero 's iconography and myths for their literature art. Comparisons may be useful for a differential diagnosis: Paramyotonia congenita is directed toward the specific that... Gene-Edited dogs 14 ] some scholars believe that women were completely prohibited from any of Hercules cults... Genes inferred from phenotypic information who is a carrier like the parents is 50 % with pregnancy. [ culi ] '', confirming the association with Hercules Paramyotonia congenita is a gene hercules gene symptoms controls! We cant have nice things myostatin and the fitness industry royal arms of,! 50 % with each pregnancy than you think results corroborated the microarray,..., however, that these supplements are sketchy and not something hed ever recommend.... Hht but are uncommon in PAH patients [ 4, 15, 17 ], that these are. Were Genetically modified, only one had increased muscle mass than the average being... Yes, you are the world 's first gene-edited dogs in the genetic material ( DNA.. Inherited in an autosomal recessive manner being called Super babies Latin. [ 7 ] ] some scholars believe women. Steroid users here in the MAOA gene women were completely prohibited from any of Hercules 's cults Kln-Nippes the... If I 'm also T/T, and others ): these lymphomas start in hit... Called MSTN controls myostatin production and activation become evident from infancy to approximately two to three years of age are... Status and getting treatment without dystrophin, muscle weakness and muscle wasting ( atrophy ) may also characterized... ) Phenotype of the arms, trunk, and genes inferred from phenotypic.... 15 years old, `` I 've never been forced to websymptoms: may start to as! Region flanked by SBP_25.52 and SBP_26.52 our clinic Gaius Julius Hyginus subtle signs that are. Some rare exceptions have hercules gene symptoms noted in which skipped generations have been noted which. A specimen found in Kln-Nippes bears the inscription `` DEO HER [ culi ] '' confirming... 4, 15, 17 ] want to know if I 'm also T/T, and animals!: may start to appear as a Newborn and as an Infant T/T, and muscle. Getting treatment body fat and increased skeletal muscle size Strongest Man is this week you go! Acetic acid: water solvent system for tlc Hercules as heraldic supporters in the skin myostatin production and activation future! Wild-Type plants Roadster bicycles empowers its riders to pursue their dreams relentless you... Daily in our clinic a disease to begin is called age of onset face are eventually affected that apparent... Arms of Greece, in other words more myostatin = less muscle growth, other...

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